January 14, 2019


Ledderhose disease is a type of plantar fibromatosis characterized by the growth of hard and round or flattened nodules (lumps) on the soles of the feet. La enfermedad de Ledderhose es una hiperproliferación benigna de fibroblastos y colágeno a nivel de la aponeurosis plantar. Patología de baja incidencia y. Fibromatosis plantar o enfermedad de Ledderhose, como causa de dolor plantar. Authors: JdD. Beas-Jiménez, R.A. Centeno-Prada, C. García-Antúnez, M.D.

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Plantar fibromatosis

Clear guidelines for who should be treated by radiotherapy and who not are still enfeermedad. Familia de 9 hermanos con 4 afectados de fibromatosis plantar y 6 con enfermedad de Dupuytren.

Version 1 – Current Version 1. People who develop initial signs of Dupuytren’s enfermedqd the age of 70 or later will often not need treatment at all. Surgery of Ledderhose’s disease is difficult because tendons, nerves, and muscles are located very closely to each other.

Fibromatosis plantar o enfermedad de Ledderhose, como causa de dolor plantar – ScienceOpen

Unable to process the form. Plantar fibromatosisor Ledderhose diseaserefers to a benign fibroblastic proliferation of the plantar fascia.

Long-term results from Betz et al. For more details please refer to ” Introduction to radiation biology when treating hyperproliferative rnfermedad diseases ” linkor literature section 9.

It is important to understand that not every patient with Dupuytren’s nodules will experience contracture. Below pictures were provided by Dr.

Palmar fibromatosis Dupuytren’s contracture KeratinCD After a break of 6 weeks, this treatment is repeated.

This condition is inherited in an autosomal dominant manner [1]. As the growth of a nodule is the net effect of building new cells and of removing dead cells, the slowing down of the growth of new cells can result in shrinking and softening of the nodule. Injections of superoxide dismutase have proven to be unsuccessful in curing the disease [9] while radiotherapy has been used successfully on Ledderhose nodules. Plantar Nodular Necrotizing Eosinophilic.


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Rev Clin Med Fam. Picture published with endermedad by the patient and H. As such, portions of the diseased tissue may be left in the foot after surgery. Palmar fibromatosis Dupuytren’s contracture Small nodules or nodular masses associated with aponeurosis and subcutaneous fat, with gray-yellow-white cut surface color depends on collagen content Plantar fibromatosis Ledderhose’s disease 2 – 3 cm nodules associated with aponeurosis and subcutis, with gray-yellow-white cut surface color depends on collagen content.

Iliotibial band syndrome Patellar tendinitis Achilles tendinitis Calcaneal spur Metatarsalgia Bone spur. Fascia with infiltrates of spindle cells.

Pathology Outlines – Fibromatosis – superficial

In other projects Wikimedia Commons. Like in wound healing this tissue maturates building cords for Dupuytren’s and eventually contracts actively or passively fixing a contraction.

Note that there is no shielding required. There is indication that this is achieved by affecting the development paths of the myofibroblast cells.

Palmar fibromatosis Dupuytren’s contracture Vimentinvariable muscle specific and smooth muscle actin in proliferative phase Plantar fibromatosis Ledderhose’s disease Vimentinvariable muscle specific and smooth muscle actin.

J Med Case Rep ;5: Even then, recognition of the imaging characteristics of plantar fibromatoses can help in the clinical diagnosis.

Picture provided by H. From Wikipedia, the free encyclopedia.

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Inadequate excision is the leading cause of recurrence. Because Ledderhose shows less cords but mostly larger nodules, radiation therapy is applied to those larger nodules as well.


The histological and ultrastructural features of Ledderhose and Dupuytren’s disease are the same, which supports the hypothesis that they have a common cause and pathogenesis. Cortisone injections, such as Triamcinolone[4] and clobetasol ointments [9] have been shown to stall the progression of the disease temporarily, although the results are subjective and large-scale studies enferkedad from complete.

Radiotherapy is the most efficient with the least recurrence rate Proc Bayl Univ Med Cent. In few cases shock waves also have been reported to at dde reduce pain and enable walking again. This disease is not very well known in primary care, probably due to its low incidence. Treatment by radiotherapy probably makes sense for patients with aggressive Dupuytren’s where RT can slow down or halt disease progression and who otherwise would have to face later surgery or frequent minimally invasive treatments.

Sonography of plantar fibromatosis. It is classified as a type of musculoskeletal fibromatosis. After radiotherapy the lederhose is not gone but reduced in size. Leddehose URI journal page: Radiotherapy seems to be able to affect the development of the involved fibroblast and myofibroblast cells in other terms the involved growth factors and reduce their growth rate. Palmar fibromatosis Dupuytren’s contracture Fibroblasts and myofibroblasts Plantar fibromatosis Ledderhose’s disease Fibroblasts and myofibroblasts Penile fibromatosis Peyronie’s Penile plaques are composed of collagen fibrils, amorphous particulate material enefrmedad fibroblasts Int J Urol ;4: Soft inner soles on footwear and padding may be helpful.