April 17, 2019


Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

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COMT inhibition in the treatment of Parkinson’s disease.

Please improve this by adding secondary or tertiary sources. Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase. COMT inhibitors include tolcaponeentacapone and opicaponewhich are used in the treatment of Parkinson’s disease. Goetz CG May It is increasingly ijhibidores that allelic variation at the COMT gene are also relevant for emotional processing, as they seem to influence the interaction between prefrontal and limbic regions.

COMT inhibition in the treatment of Parkinson’s disease.

Both pharmacokinetically and clinically the mg dose of entacapone is the most effective dose compared with placebo. Principles of pharmacology 3rd ed. Journal of Alzheimer’s Disease. EC number Enzyme superfamily Inhibicores family List of enzymes. Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase.


Views Read Edit View history. Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase.

Research conducted at the Section of Neurobiology of PsychosisInstitute of Psychiatry, King’s College London has demonstrated an effect of COMT both in patients with bipolar disorder and in their relatives, [36] [ unreliable medical source ] but these findings have not been replicated so far.

Molecular and Cellular Biology portal.

American Journal of Human Genetics. The American Journal of Psychiatry.

Journal of Oral Rehabilitation. COMT is the name given to the gene that codes for this enzyme.

Catechol-O-methyltransferase – Wikipedia

Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. Retrieved November 16, Lay summary — MedWireNews. Hydroxymethyltransferase Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase. Oroszi G, Goldman D December The gene is associated with allelic variants.

ES2282924T3 – Inhibidores de la comt. – Google Patents

Their effects and significance also in the treatment of de novo patients need to be clarified. Cholinesterase AcetylcholinesteraseButyrylcholinesterase.

Histamine N-methyltransferase Diamine oxidase. Zhu Inhibidorse October Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. However, there seems to be a trend for tolcapone to induce more often diarrhoea and increase in liver transaminases compared with entacapone.


This page was last edited on 21 Novemberat December Learn how and when to remove this template message. The effect size of genotypic moderation was quite large: A functional single-nucleotide polymorphism a common normal variant of the gene for catechol-O-methyltransferase results in a valine to methionine mutation at position Val Met rs Two of the nitrocatechols, entacapone All articles with dead external links Articles with dead external links from November Articles with permanently dead external links Articles lacking reliable references from December All articles lacking reliable references Commons category link is on Wikidata.