December 31, 2018


7 jun. Rabdomiólise, uma palavra que é muito importante no mundo dos “gymmers”. Sabe porquê? Trata-se de uma síndrome grave provocada pelo. Rhabdomyolysis is a process of muscle destruction that can present with varying clinical manifestations. In pediatric patients, its main etiology is infectious. Esse relato descreve o caso de uma mulher com lúpus eritematoso sistêmico ( LES) que sofreu rabdomiólise em seguida à sua infecção pelo vírus da dengue.

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Need a Curbside Consult? A year-old girl was admitted to our emergency department with a four-day history of generalized myalgia, muscular weakness and dark urine. However, other etiologies can be found and include trauma, exercise, drugs, toxins, and metabolic and electrolyte disorders. Researchers believe that viruses may cause rhabdomyolysis by directly attacking the muscle and generating muscle-specific toxin. Management of crush-related injuries after disasters.

Colchicine triggered severe rhabdomyolysis after long-term low-dose simvastatin therapy: The adult form has a good prognosis if rhabdomyolysis is avoided. Muscle painsweakness, vomitingconfusiontea-colored urine, irregular heartbeat [3] [4]. Rhabdomyolysis is characterized by muscle necrosis that results in the release of muscles constituents, including myoglobin, into circulation.

It has been referred to as “atypical myopathy” or “myoglobinuria of unknown etiology”. Med Sci Sports Exerc. Because of inadequate ATP production, the mismatch of energy supply and demand may result in the disruption of cell membranes during exercise.

Wrenn KD, Oschner I. Prophylactic fluid therapy in crushed victims of Bam earthquake. Francisella tularensis [ 1424 ]. The remainder of her physical examination was rabbdomiolise. Electrophysiologic and laboratory aids in the diagnosis of neuromuscular disease”.

Carbon monoxide [ 54 ]. The treatment of disseminated intravascular coagulation is mainly supportive and depends on the overall treatment of rhabdomyolysis. Received Aug 16; Accepted Oct 8. Statins 3-hydroxymethylglutaryl coenzyme A reductase inhibitors [ 424344 ].


A comparable figure in children is unavailable.

Sensitive laboratory markers of myocyte injury include elevated plasma creatine kinase CK levels often in excess of 4- to 5-fold the rabdomjolise limit of normal.

Am J Med Sci. Rabdomioolise aftermath of the Spitak earthquake prompted the establishment, inof the Renal Disaster Relief Task Force, a working group of the International Society of Nephrology a worldwide body of kidney experts. This report describes the case of a woman with systemic lupus erythematous SLE that developed rhabdomyolysis after being infected by dengue virus.

Rhabdomyolysis is a rabdomjolise condition in adult populations and is understudied in pediatrics. Practice Essentials Rhabdomyolysis is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma.

At discharge, her renal function was recovering, and she had a glomerular filtration rate of High pressures in the compartment and a small difference between compartment pressure and blood pressure indicate that the blood supply is likely to be insufficient, and that rabdomillise intervention may be needed.

Of these, some cause isolated attacks of rhabdomyolysis e. Rhabdomyolysis as a complication of respiratory failure and status epilepticus or status asthmaticus has been reported. Clin Chem Lab Med. Its final common pathway may be a disturbance in myocyte calcium homeostasis. Some of these deficiencies are treatable with dietary modification.

On day 5, intermittent hemodialysis was started, and three sessions on alternate days were performed. Fasting and intense exercise should be avoided. American Academy of Pediatrics. The major therapeutic interventions in rhabdomyolysis are conservative.

A rabdomiólise está associada à febre dengue em um paciente lúpico – ScienceDirect

It is also more common in the elderly, those who are severely disabled, and when statins are used in combination with particular other medicines, such as ciclosporin.


With adequate supportive measures, the clinical outcome of rhabdomyolysis is often favorable in children. For instance, mitochondrial diseases are characterized by ragged red fibers. Arterial thrombosis blood clots forming locally or embolism clots or other debris from elsewhere in the bodyclamping of an artery during surgery [4] [6]. Hemlock herbs from quail — Rhabdomyolysis after the consumption of quail is well known in the Mediterranean region; it occurs as the result of intoxication by hemlock herbs that the quails consume.

Life-threatening renal failure and disseminated intravascular coagulation DIC are dreaded complications that appear to be more common in adults. Large numbers of patients may develop rhabdomyolysis and renal failure during disasters such as earthquakes.

Luck RP, Verbin S. Treatment units are generally established outside the immediate disaster area, as aftershocks could potentially injure or kill staff and make equipment unusable.

Sabe o que é a rabdomiólise?

N Engl J Med. Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis.

This ischemia leads to endotoxin absorption, cytokine production, and perpetuation of the systemic inflammatory response. Deep tendon reflexes were normal, and there was no neurologic deficit. Footnotes Conflicts of interest: The following hereditary disorders of the muscle energy supply may cause recurrent and radbomiolise exertional rhabdomyolysis: